Effects of compound danshen tablet on the expression of Abeta in transgenic cell model of Alzheimer's disease / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of Compound Danshen Tablet (CDT) on the expression of the beta-amyloid peptide (Abeta) in transgenic cell model of Alzheimer's disease (AD).</p><p><b>METHODS</b>The previously successfully cultured transgenic cell model was used as AD transgenic cell model. Rats were fed with 0.5, 1, 2, and 4 times CDT. The AD transgenic cells were cultured in 0.5, 1, 2, and 4 times rats' sera. The expressions of Abeta in transgenic cells were detected using Western blot.</p><p><b>RESULTS</b>The optimal dose effect was obtained in the 1 time CDT group at 24 h.</p><p><b>CONCLUSION</b>CDT could reduce the Abeta expression level in the AD transgenic cell model.</p>