Analysis of Factors Influencing Peripheral Blood Stem Cell Collection of 151 Lymphoma Cases / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 416-421, 2016.
Article
en Zh
| WPRIM
| ID: wpr-360075
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the influential factors related to mobilization and collection of stem cells so as to improve the collection efficiency of autologous peripheral stem cell transplantation in lymphoma patients.</p><p><b>METHODS</b>The peripheral blood stem cell collection data of 151 cases of lymphoma in our hospital was analyzed retrospectively. The relationship between the harvested CD34(+) stem cells and some factors, such as age, sex, height, weight, histological type, staging, mobilization programs, collecting days, blood transfusion, time and duration of chemotherapy, was analyzed.</p><p><b>RESULTS</b>The single factor analysis showed that sex, height, weight, histological type, staging, mobilization program, collecting days, blood transfusion were not significantly associated with CD34(+) stem cells collection, respectively. Age (r = -0.248, P = 0.002), duration of sick and cycles of chemotherapy were significantly associated with CD34(+) cell collection. At the age older than 50 years, the collected CD34(+) cell number decreased significantly; and at the age older than 60 years, the CD34(+) cell number was greatly reduced; CD34(+) cells non-significantly correlated with peripheral blood WBC (r = 0.053, P = 0.527), but significantly with the percentage of mononuclear cells (r = 0.260, P = 0.002) and the absolute value of mononuclear cells (r = 0.338, P = 0.00003) .</p><p><b>CONCLUSION</b>The patients less than 60 years old, fewer chemotherapy cycles, shorter duration time or PB mononuclear cells between (2-6) × 10(9)/L may contribute to the better mobilization and collection of peripheral blood stem cells.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Terapéutica
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Trasplante Autólogo
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Transfusión Sanguínea
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Células Madre Hematopoyéticas
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Recuento de Células
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Estudios Retrospectivos
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Factores de Edad
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Antígenos CD34
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Movilización de Célula Madre Hematopoyética
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Biología Celular
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2016
Tipo del documento:
Article