miRNA and its prospect in HCC diagnosis and prognosis / 肿瘤研究与临床

ABSTRACT

miRNA have been discovered as naturally occurring non-coding RNA, controlling gene expression via specific sites at the 3'-UTR of target-mRNA, causing translational repression or degradation.The aim of this paper is to introduce the relationship of microRNA and carcinogenesis in liver cancer and the progress of tissue or serum microRNA as the potential clinical biomarkers of HCC. Though much difficulty remains in the microRNA as biomarker studies, more evidences indeed prove the associations between the tissue or serum microRNA profiles and the carcinogenesis. Specially, the serum microRNA detection is lowinvasive and easy to handle, indicating microRNA might to be useful biomarkers for HCC diagnosis or prognosis.