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Cognitive function changes in response to expression of glucocorticoid recepmr from rat hippocampus after traumatic brain injury / 中华创伤杂志
Chinese Journal of Trauma ; (12): 555-558, 2011.
Article en Zh | WPRIM | ID: wpr-416444
Biblioteca responsable: WPRO
ABSTRACT
Objective To explore the effect of glucocorticoid receptor(GR)expression in rat hippocampus on cognitive function after traumatic brain injury(TBI). Methods The TBI model wag established in rats.Then,immunohistochemistry and Western blot were used to detect the GR expression and evaluate its relation with cognitire dysfunction by Morris water maze. Results Expression of hippocampal GR was down-regulated 4-10 days after TBI.Morris water maze test showed significant impairment of the cognitive function in rats. Conclusion There is correlation between expression change of hippocampal GR and cognitive dysfunction.
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Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Journal of Trauma Año: 2011 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Journal of Trauma Año: 2011 Tipo del documento: Article