Role of phosphorylation of p53 at Ser392 in cancer therapy / 解剖学报
Acta Anatomica Sinica
; (6): 437-440, 2014.
Article
en Zh
| WPRIM
| ID: wpr-451000
Biblioteca responsable:
WPRO
ABSTRACT
Phosphorylation is the most common way of p 53 post-translational modifications .However , gaps still exist in our knowledge regarding the role and mechanism of phosphorylation of p 53 at Ser392 in carcinogenesis and cancer prevention.In the present study, we summarized the effect of phos-p53-Ser392 to wild-type and mutant p53, the regulation by DNA damage agents and protein kinase , and the significance of phosphorylation of p 53-Ser392 in cancer treatment .
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1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Acta Anatomica Sinica
Año:
2014
Tipo del documento:
Article