Association between maternal MTHFR C677T polymorphism and neural tube defects in offsprings:a Meta-analysis / 天津医药
Tianjin Medical Journal
; (12): 552-558, 2015.
Article
en Zh
| WPRIM
| ID: wpr-473847
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the association between maternal methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and neural tube defects (NTDs). Methods CBM, VIP, CNKI, Wanfang, PubMed and Web of Science databases from set up to March, 2014 were electronically searched to identify case-control studies on the relationship between maternal MTHFR C677T polymorphism and NTDs. The data were quantitatively analyzed by RevMan 5.0 software. Results A total of 25 studies were selected including 2 282 cases and 3 420 controls. Overall, the pooled OR (with 95%CI) under co-dominant model and allele contrast were 2.28(1.60-3.24), 1.25(1.02-1.53) and 1.42(1.21-1.67). Subgroup analysis showed significant association between maternal MTHFR C677T polymorphism and NTDs susceptibility in Asian populations. Conclusion The present meta-analysis suggests that MTHFR C677T polymorphism is significantly associated with maternal risk for NTDs, especially in Asian populations.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
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Systematic_reviews
Idioma:
Zh
Revista:
Tianjin Medical Journal
Año:
2015
Tipo del documento:
Article