A Study on CpG Island Methylator Phenotype involving Tumor Suppressor Genes on Chromosome 3p in Gastric Cancer / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 587-591, 2015.
Article
en Zh
| WPRIM
| ID: wpr-481067
Biblioteca responsable:
WPRO
ABSTRACT
Background:
CpG island methylator phenotype(CIMP)involving tumor suppressor gene( TSG)on short arm of chromosome 3(chromosome 3p)has been found in various types of cancers. However,its correlation with gastric cancer has not been clarified.Aims:
To study the clinical significance of CIMP involving TSG on chromosome 3p in gastric cancer.Methods:
Methylation specific PCR(MSP)was used to examine methylation profiles for hOGG1,VHL,RAR-B, hMLH1,SEMA3B,RASSF1A,BLU and FHIT harbored in chromosome 3p in 100 gastric cancer and paired paracancerous tissues. High CIMP( CIMP-H)was referred for those samples having four or more synchronously methylated genes. Relationship between CIMP-H and clinicopathological characteristics in gastric cancer was analyzed.Results:
Positive methylation rates of VHL(P = 0. 030),hMLH1(P 0. 05).Conclusions:
CIMP on chromosome 3p may occur in early stage of oncogenesis of gastric cancer,and influencing tumor differentiation and lymph node metastasis.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Gastroenterology
Año:
2015
Tipo del documento:
Article