Research progress of TGIF in related signaling pathways and tumours / 国际外科学杂志
International Journal of Surgery
; (12): 128-132, 2016.
Article
en Zh
| WPRIM
| ID: wpr-489605
Biblioteca responsable:
WPRO
ABSTRACT
As a nuclear transcription repressor,the functions of TGIF are complicated,not only represses target genes expression directly,but also takes part in the regulation of multiple important cellular signaling pathways,which are associated with the differentiation of cells and tissues,inflammation,metabolism and tumors.In past few years,more and more studies on the role of TGIF in tumors suggest TGIF may be a new therapy target in the diagnosis and treatment of tumours.This article mainly reviews the research progress of TGIF in some signaling pathways like TGF-β,MAPK,PI3K/AKT,and tumours like hepatocellular carcinoma,lung carcinoma and urinary tract urothelial carcinoma.
Texto completo:
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
International Journal of Surgery
Año:
2016
Tipo del documento:
Article