Phylogeny and drug resistance of HIV PR gene among HIV patients receiving RT inhibitors in Iran
Asian Pacific Journal of Tropical Biomedicine
; (12): 451-454, 2016.
Article
en Zh
| WPRIM
| ID: wpr-499660
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To survey the level and patterns of reverse transcriptase-based drug resistance and subtype distribution among antiretroviral-treated HIV-infected patients receiving only reverse transcriptase inhibitors in Iran.Methods:
A total of 25 samples of antiretroviral therapy experienced patients with no history of using protease inhibitors were collected. After RNA extraction, reverse transcriptase-nested PCR was performed. The final products were sequenced and then analysed for drug-resistant mutations and subtypes.Results:
No drug resistant mutations were observed among the 25 subjects. The results showed the following subtypes among patientsCRF 35_AD (88%), CRF 28_BF (8%), and CRF 29_BF (4%).Conclusions:
A significant increase in drug resistance has been noted in recently-infected patients worldwide. Subtype distributions are needed to perform properly-designed surveillance studies to continuously monitor rates and patterns of transmitted drug resistance and subtypes to help guide therapeutic approaches and limit transmission of these variants.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Qualitative_research
Idioma:
Zh
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2016
Tipo del documento:
Article