Effects of Sanguis draxonis on wound healing in rat models of tissue-engineered skin transplantation / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
; (53): 5524-5529, 2016.
Article
en Zh
| WPRIM
| ID: wpr-503486
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
Increasing evidence suggests that Sanguis draxonis is of great significance for treating pressure sores, burns and ulcers.OBJECTIVE:
To observe the influences of Sanguis draxonis on vascular endothelial growth factor, epidermal growth factor, substance P and hydroxyproline in rats undergoing tissue-engineered skin transplantation and to verify its promotion of wound repair.METHODS:
The tissue-engineered skin transplantation model of rats were established. Rats in treatment groups were given external application, single oral use of 0.1 g/(kg·d) Sanguis draxonis and combined use, respectively. No treatment was given in control group. After continuous treatment for 7 days, the expression levels of vascular endothelial growth factor, epidermal growth factor, substance P and hydroxyproline in skin tissue were determined. RESULTS ANDCONCLUSION:
Compared with the control group, the levels of vascular endothelial growth factor, epidermal growth factor, and hydroxyproline were significantly increased (P0.05). These results demonstrate that Sanguis draxonis can promote tissue-engineered skin to repair skin wound by upregulating the expression levels of vascular endothelial growth factor, epidermal growth factor, and hydroxyproline.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Tissue Engineering Research
Año:
2016
Tipo del documento:
Article