Determination of Contents, Extraction and Migration of Mg and Al in Polypropylene Infusion Bottles by ICP-MS / 中国药师

ABSTRACT

Objective:To establish an ICP-MS method to determine the contents, extraction and migration of Mg and Al in poly-propylene infusion bottles. Methods:An ignition pretreatment method was adopted to determine the contents of Mg and Al in the mate-rials. Five different extraction media with extreme extraction were used to extract and test Mg and Al in polypropylene infusion bottles. Three injections commonly used in clinics were put into polypropylene infusion bottles to carry out accelerated experiment, and the con-tents of Mg and Al were determined by ICP-MS. Results:Mg and Al both had a good linear relationship within the range of 0. 025-1. 0μg·ml-1 (r =0.999 8 and 0.999 0). The recoveries for polypropylene infusion bottles and extraction and migration test were 93. 77%-105. 0% and 96. 53%-103. 89% with RSD of 0. 4%-6. 9% and 1. 0%-7. 1%(n=9), respectively. Conclusion:The meth-od is accurate, sensitive and simple, which can provide reference for the safety data of polypropylene infusion bottles.