Observation of the effect of bismuth pectin combined with aluminium phosphate gel in the treatment of chronic atrophic gastritis / 中国基层医药

ABSTRACT

Objective To observe the clinical efficacy of bismuth pectin combined with aluminium phosphate gel in the treatment of chronic atrophic gastritis.Methods 110 patients with chronic atrophic gastritis were randomly divided into observation group(n =55) and control group(n =55).The observation group received bismuth pectin combined with aluminium phosphate gel treatment,the control group received bismuth pectin and amoxicillin treatment.The occurrence of pathological changes of integral clinical efficacy and adverse reaction were compared between the two groups.Results The total effective rate of the observation group was 87.27％,which was significantly higher than 74.55％ of the control group (x2 =5.238,P ＜ 0.05).The atrophy,intestinal metaplasia,dysplasia,chronic inflammation,activity of pathological scores in the observation group were (2.36 ± 0.79) points,(1.11 ± 0.18) points,(2.19 ± 0.54) points,(1.35 ± 0.27) points,(0.43 ± 0.16) points,respectively,which were significantly lower than (1.44 ± 0.57) points,(0.48 ± 0.29) points,(1.38 ± 0.52) points,(0.69 ± 0.22) points,(0.21 ± 0.09) points in the control group (t =7.004,13.688,8.013,7.240,8.888,all P ＜ 0.05).The incidence rate of adverse reactions of the observation group was 5.45％,which was significantly lower than 18.18％ of the control group (x2 =7.777,P ＜ 0.05).Conclusion Bismuth pectin combined with aluminium phosphate gel in the treatment of chronic atrophic gastritis can significantly reduce the clinical symptoms,and has better clinical curative effect,low incidence of adverse reactions,it is safe,reliable and worthy of promotion in clinical.