Comparision of immunogenicity of vaccine produced by different rabies the strain / 中国免疫学杂志

ABSTRACT

To compare immunogenicity of vaccine produced by three rabies virus stains( aG-,CTN.,CaG) respectively and determine their the ability against lethel challenge of rabies virus.Methods: By ELISA to determine sera potency of rabbits as well as hamsters and guinea-pigs which have been vaccinated different rabies respectively .To neutralize three different rabies strain with sera of hamster vaccinated and carry on neutralization experiments in mice.Results:In rabbits and guinea-pigs groups,rabies vaccine protency(by ELISA determination) vaccinated cell-adapted virus strain (CaG and CTN) is higher than one of vaccinated guinea-pig' strain virus strain's (aG), sera ability of hamster vaccinated cell-adapted strain against three rabies virus lethel challenge is higher than one of guinea-pig strain virus strain' g, too. Conclusion: Immunogenicity of rabies vaccine produced by cell-adapted strain is better than one of guinea-pig'sbrain virus strain's.