Study on the polymorphism of (CAG)n repeats within androgen receptor gene in patients with prostate cancer / 中华泌尿外科杂志
Chinese Journal of Urology
; (12)2001.
Article
en Zh
| WPRIM
| ID: wpr-536987
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study the relationship between polymorphic (CAG)n repeats of androgen receptor(AR) gene and occurrence of prostate cancer (PC). Methods (CAG)n repeats of both malignant cells and adjacent nonmalignant cells from 34 paraffin embedded PCs, and that of peripheral blood cells from 2 PC patients were assessed using dsDNA cycle sequencing. Results The number of (CAG)n repeats in malignant cells was equal to that in adjacent nonmalignant cells from the same paraffin embedded PC; the mean of (CAG)n repeats in the 36 PC patients was 20.06 which was significantly smaller than that of normal men ( P 0.05). Conclusions Shortening of (CAG)n repeats within AR gene may be associated with the occurrence of PC.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Urology
Año:
2001
Tipo del documento:
Article