A case of levocetirizine-induced liver injury
Clinical and Molecular Hepatology
; : 495-498, 2016.
Article
en En
| WPRIM
| ID: wpr-54508
Biblioteca responsable:
WPRO
ABSTRACT
Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings. A 48-year-old man was hospitalized with jaundice and generalized pruritus that had developed after 2 months of therapy with levocetirizine for prurigo nodularis. Laboratory findings revealed acute hepatitis with cholestasis. A liver biopsy demonstrated portal inflammation and hepatitis with apoptotic hepatocytes. The patient fully recovered 3 weeks after withdrawing levocetirizine. Although levocetirizine is safe and effective, physicians should be aware of its potential hepatotoxicity.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Prurito
/
Cetirizina
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Antagonistas de los Receptores Histamínicos H1 no Sedantes
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Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hipersensibilidad
/
Ictericia
/
Hígado
Límite:
Humans
/
Male
Idioma:
En
Revista:
Clinical and Molecular Hepatology
Año:
2016
Tipo del documento:
Article