INCIDENCE OF CYTOMEGALOVIRUS PP65 ANTIGENEMIA AND ITS CLINICAL OUTCOME IN PATIENTS FOLLOWING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION / 解放军医学杂志
Article
en Zh
| WPRIM
| ID: wpr-552984
Biblioteca responsable:
WPRO
ABSTRACT
CMV related matrix protein pp65 antigenemia was screened in 100 Allo HSCT patients after transplantation. As control groups, samples from fourteen autologous HSCT patients, seventeen patients with various hematological malignant disorders, as well as twenty seven normal donors also were detected. CMV antigenemia was found in 91/100 Allo HSCT patients (91%) after transplantation. 56 % patients with antigenemia developed CMV disease. 54% patients developed acute GVHD. In 87 patients survived more than three months, 52 9% patients developed chronic GVHD. After follow up 18(4~36) months post transplantation, 21 patients died of CMV related diseases. Compared with autologous and non transplantation patients, CMV antigenemia and CMV diseases were particularly associated with Allo HSCT patients. It was obviously correlated with acute and chronic GVHD. CMV infection is a major factor affecting the clinical outcome of Allo HSCT patients.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Incidence_studies
Idioma:
Zh
Revista:
Medical Journal of Chinese People's Liberation Army
Año:
2001
Tipo del documento:
Article