Airway hyperresponsiveness among workers exposed to isocyanates at Yeocheon petrochemical plant / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
; : 468-475, 1999.
Article
en Ko
| WPRIM
| ID: wpr-56746
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To investigate the prevalence of airway hyperresponsiveness induced by isocyanate at one petrochemical industry complex in Yeochon, Korea. METHOD: Questionnaires, allergic skin prick test, toluene diisocyanate (TDI)-specific IgE, and non-specific airway hyperresponsiveness (AHR) were studied in 73 exposed workers and 27 control subjects. Methacholine challenge tests were done and bronc hial responsiveness (BR index) was defined as log (% fall of FEV1)/ log (last concentration of methacholine +10). RESULTS: Twenty-three workers (31.5% ) had respiratory symptoms, 21 had nasal symptoms, and eight had skin symptoms. Exposed workers with respiratory symptoms (n=22) had significantly higher BR index than those without them (0.82+/-0.06 vs 0.60+/-0.02, p0.05). Specific IgE antibodies were found in 19.7% of exposed workers. FEV, showed a significant negative correlation with BR index (r =-0.25, p<0.05). Poor correlation was noted between BR index and atopy, smoking status, or exposure duration. CONCLUSION: These findings suggest that workers exposed to isocyanates are at higher risk of airway hyperresponsiveness.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Plantas
/
Piel
/
Humo
/
Inmunoglobulina E
/
Fumar
/
Prevalencia
/
Encuestas y Cuestionarios
/
Cloruro de Metacolina
/
Isocianatos
/
2,4-Diisocianato de Tolueno
Tipo de estudio:
Prevalence_studies
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Año:
1999
Tipo del documento:
Article