Experimental study and preliminary clinical application of microwave coagulation therapy for hepatic malig-nancies after interruption of hepatic blood flow / 介入放射学杂志

ABSTRACT

Objective To investigate the change on the extent of coagulated lesion under various interrupting methods of hepatic blood flow in vivo animal livers, and the clinical effect of combining tran scathcter arterial chernoembolization(TACE) with percutaneous microwave coagulation therapy (PMCT) for primary and metastatic hepatic tumors. Methods Using FORSEA MTC-3-500s microwave coagulator, we performed microwave tissue coagulation in vivo liver of 6 pigs at 60 W, 2 min and of 20 rabbits al 40 W, 2 min with or without the interruption of hepatic blood flow. 27 patients with primary hepatic carcinoma(30 nodules) and 8 patients with metastatic carcinoma( 12 nodules) underwent the combination therapy of 1 - 4 sessions of TACK followed by within 3-10 days by 1 - 3 sessions of PMCT guided by ultrasonography and/or CT. The 42 lesions measured from 2. 3 cm to 15.6 cm were taken place. Results In vivo liver, the greatest dimension of the lesions coagulated by microwave with the interruption of hepatic arterial and portal flow were 22.510.6 mm at 40 W, 2 min and 28. 6?1. 2 mm at 60 W, 2 min, which were markedly larger than those without the interruption (13.3?0.3; and 15.6?0.7 mm, P