Quality control of Compound Glucomannan Weight-reducing Tablet / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
en Zh
| WPRIM
| ID: wpr-580415
Biblioteca responsable:
WPRO
ABSTRACT
AIM:
To establish the quality control standard of Compound Glucomannan Weight-reducing Tablet.METHODS:
Material and tablets went through ultrasonic cleaning by 60% alcohol and then hydrolyzed to glucose and mannose with 2.0 mol/L sulfuric acid,derivatized with PMP,separated by RP-HPLC using a stage gradient elution,and wavelength was at 250 nm. The monosaccharide were studied under the help of internal standard; while the glucomannan content in Konjac refined powder and tablets was determined.RESULTS:
Linearities of glucose and mannose were good (r=0.994 3,0.999 8) in the range of 0.05-0.5 mmol/L.The average recoveries of this method were 100.67% and 98.34%,RSD were 2.74% and 3.22%(n=5) respectively. Ratio of glucose to mannose in glucomannan was 2 ∶3,glucomannan content in Konjac refined powder was 88.2%,glucomannan content in tablet was 354 mg/p. dissolution used for glucomannan conformed to homogeneity.CONCLUSION:
The established quality standard is simple,feasible and reproducible,and can be used for quality control of Compound Glucomannan Weight-reducing Tablet.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional Patent Medicine
Año:
1992
Tipo del documento:
Article