Expressing changes of nitric oxide synthase in substantia nigra and striatum of hemiparkinsonism monkey model / 临床神经病学杂志
Journal of Clinical Neurology
; (6)1995.
Article
en Zh
| WPRIM
| ID: wpr-589762
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the expressing changes of nitric oxide synthase(NOS) in substantia nigra and striatum of the hemiparkinsonism monkey model.Methods Three hemiparkinsonian rhesus monkey models were induced by injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) unilaterally into the internal carotid artery.The expressing changes of NOS-positive neurons of substantia nigra and striatum in three hemiparkinsonism monkey models and one normal control monkey were observed by using NADPH-diaphorase histochemistry staining method.Results The NOS-positive neurons were increased significantly in the substantia nigra and striatum of MPTP lesioned side of hemiparkinsonian monkey model compared to contralateral side and normal control monkey(all P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Clinical Neurology
Año:
1995
Tipo del documento:
Article