Curative effect and influence on memory function of Gabapentin as add-on therapy for treatment of focal seizures in refractory epilepsy / 临床神经病学杂志

ABSTRACT

Objective To study the curative effect and influence on memory function of Gabapentin (GBP) as add-on therapy for treatment of focal seizures in refractory epilepsy. Methods 96 patients with focal seizures in refractory epilepsy were randomly divided into groups GBP and Topiramate (TPM). Beside the normal medicaments, GBP or TPM as add-on therapy for certain group. According to the Clinical Memory Scale (CMS), the patient's memory function was evaluated before and after treatment. Results There was no significantly difference of total effective rate between groups GBP (75.0%) and TPM (72.9%). The scores of CMS showed almost same between before or after add-on therapy in GBP group. In TPM group, the scores of meaningless image recognition, free recall, phase portrait characteristics and memory quotient were significantly reduced after add TPM(allP