Changes and its clinical significance of frontal lobe magnetic resonance spectroscopy in patients with Parkinson's disease / 临床神经病学杂志
Journal of Clinical Neurology
; (6)2001.
Article
en Zh
| WPRIM
| ID: wpr-593009
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the changes and its clinical significance of frontal lobe magnetic resonance spectroscopy(1H-MRS) in patients with Parkinson's disease(PD).Methods 1H-MRS localized to both frontal lobe,was carried out in 36 patients with PD(14 patients with Hoehn-Yahr stageⅠ,8 patients with Hoehn-Yahr stage Ⅱ,8 patients with Hoehn-Yahr stage Ⅲ,and 6 patients with Hoehn-Yahr stage Ⅳ) and 20 age-matched healthy control subjects.The metabolite ratios of N-acetylasparatate(NAA)/creatine(Cr),and choline-containing compounds(Cho)/Cr in patients with PD on different stage were compared with those in normal control group.Results NAA/Cr ratios were reduced significantly and Cho/Cr ratios were increased significantly in both frontal lobe in patients with Hoehn-Yahr stageⅢ and Ⅳ compared to those in normal control group(P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Clinical Neurology
Año:
2001
Tipo del documento:
Article