Effects of berberine on the prevention of left ventricular remodeling after acute myocardial infarction / 中国介入心脏病学杂志
Chinese Journal of Interventional Cardiology
; (4)2003.
Article
en Zh
| WPRIM
| ID: wpr-596772
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the effects of berberine(BBR)on the prevention of left ventricular remodeling after acute myocardial infarction(AMI)in New Zealand rabbits.Methods AMI were conducted by ligating left coronary artery in female New Zealand rabbits.Five days after the procedure,the 28 survival rabbits were randomized into the controls(n=14)or BBR treatment group [n=14,BBR 8 mg/(kg?d)iv.].Hemodynamic studies were performed 4 weeks after the completion of treatment.Pathology study of the rabbits hearts was carried ont and matrix metalloproteinases(MMPs)2 and 9 were detected by immunohistochemical analysis in the non-infarct myocardium.Results Compared with the control group,left ventricular relative weight(LVRW)and LV end diastolic pressure(LVEDP)were decreased in the treatment group 4 weeks after BBR intervention(1.55?0.12 vs 1.69?0.13,P
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1
Base de datos:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Revista:
Chinese Journal of Interventional Cardiology
Año:
2003
Tipo del documento:
Article