Expression of hepatocyte growth factor and its receptor c-Met in colorectal cancer and their significances / 肿瘤研究与临床

ABSTRACT

Objective To investigate the expression of hepatocyte growth factor (HGF) and its receptor c-Met in colorectal cancer tissues and their clinical significances.Methods 100 patients with colorectal cancer who accepted treatment from March 2012 to 2015 February were collected.The immunohistochemical method was used to test the expression of HGF and c-Met in tumor tissues.The correlation of clinicopathological parameters and lymphatic microvessel density (LMVD) was analyzed.Results The positive expression rates of HGF in patients with or without lymph node metastasis were 100.0 ％ (35/35) and 41.5 ％ (27/65),the difference had statistical significance (x2 =6.99,P ＜ 0.05).The positive expression rates of c-Met were 94.3 ％ (33/35) and 47.7 ％ (31/65),the difference was statistically significant (x2 =7.75,P ＜ 0.05).The positive expression rates of HGF in patients with TNM stage Ⅰ + Ⅱ and Ⅲ + Ⅳ were 48.6 ％ (17/35) and 69.2 ％ (45/65),the difference had statistical significance (x2 =5.94,P ＜ 0.05).The positive expression rates of c-Met were 51.4 ％ (18/35) and 70.8 ％ (46/65),the difference was statistically significant (x2 =6.08,P ＜ 0.05).The LMVD of patients with different lymph node metastasis,tumor stage,HGF and its receptor c-Met expression were statistically different (t values were 10.19,10.08,7.50,5.07,all P ＜ 0.05).Conclusion HGF and its receptor c-Met is closely related to the development of colorectal cancer.They can help the diagnosis,and be used as new targets in the treatment of colorectal cancer.