Cytogenetic Study in 535 Couples with Recurrent Spontaneous Abortions in Korea / 대한불임학회지
Korean Journal of Fertility and Sterility
; : 113-120, 2005.
Article
en Ko
| WPRIM
| ID: wpr-60749
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: The purposes of this study were to investigate the types and the incidences of chromosomal abnormalities, and to provide an explanation for the genetic causations of recurrent spontaneous abortions in Korean population. METHODS: Cytogenetic studies were carried out in 535 couples with at least two spontaneous first trimester abortions from January 1981 to December 2003. For karyotype analysis, we used modified Moorhead method by Giemsa staining and Giemsa-Trypsin-Giemsa banding RESULTS: The overall incidence of chromosome abnormality was 32 out of 535 cases (5.98%). There were 25 cases (4.67%) of translocation and 7 cases (1.31%) of inversion. In translocation, 5 cases (0.93%) of Robertsonian translocation and 20 cases (3.74%) of reciprocal translocation were observed. In inversion, 6 cases (1.12%) of inversion of chromosome 9 and one case (0.19%) of inversion of chromosome 18 were found. CONCLUSION: In this study, overall chromosomal abnormality rate in couples with recurrent spontaneous abortions is much higher than that in the general population. So, chromosomal analysis should be offered for the prognostic information in genetic counseling such as prenatal diagnosis in couples with repetitive reproductive failure.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Primer Trimestre del Embarazo
/
Diagnóstico Prenatal
/
Colorantes Azulados
/
Cromosomas Humanos Par 9
/
Cromosomas Humanos Par 18
/
Aborto Espontáneo
/
Composición Familiar
/
Incidencia
/
Aberraciones Cromosómicas
/
Citogenética
Tipo de estudio:
Diagnostic_studies
/
Incidence_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Fertility and Sterility
Año:
2005
Tipo del documento:
Article