Extrapyramidal Signs and Impairment of Cognitive Subdomains in Mild Cognitive Impairment : A Clinical Research Center for Dementia of South Korea (CREDOS) Study
Journal of Korean Geriatric Psychiatry
; : 72-78, 2015.
Article
en Ko
| WPRIM
| ID: wpr-63678
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES:
This study investigated the association between extrapyramidal signs (EPS) and five cognitive sub-domains in a large number of patients with mild cognitive impairment (MCI).METHODS:
Our analyses considered 1,943 patients with MCI drawn from the nationwide Clinical Research of Dementia of South Korea study. EPS were defined as presence in patients with at least 1 of 11 operationally specified features. We assessed five cognitive sub-domains attention, language, visuospatial function, memory, and frontal/executive function using the Seoul Neuropsychological Screening Battery-Dementia version. The associations of EPS with each cognitive sub-domain were analyzed with a multiple linear regression model after controlling for confounding factors sex, age, education years, diabetes, hypertension, severity of global function, depressive symptoms, and white matter hyperintensities (WMH).RESULTS:
138 MCI patients (7.1%%) had EPS. This group had more global cognitive deterioration and severe WMH. MCI patients with EPS showed lower performance compared to those without EPS in 3 cognitive sub-domains attention (p=0.05), visuospatial function (p=0.02), and frontal/executive function (p<0.0001). The language sub-domain and the memory sub-domain did not differ between the EPS positive and the EPS negative groups.CONCLUSION:
EPS in MCI are associated with greater cognitive impairment in specific functional sub-domains rather than with global greater cognitive deterioration.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Modelos Lineales
/
Tamizaje Masivo
/
Cognición
/
Demencia
/
Depresión
/
Educación
/
Disfunción Cognitiva
/
Seúl
/
Hipertensión
/
Corea (Geográfico)
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Journal of Korean Geriatric Psychiatry
Año:
2015
Tipo del documento:
Article