Effect on Blood Lipid and Hepatoprotective Efficacy of Hemp Seed Oil in Hyperlipidemic Rats / 中国药师
China Pharmacist
; (12): 571-573,597, 2015.
Article
en Zh
| WPRIM
| ID: wpr-671150
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WPRO
ABSTRACT
Objective:
To observe the effect of hemp seed oil on the blood lipid and its hepatoprotective efficacy in hyperlipidemic rats.Methods:
High fat diet was used to make the hyperlipidemia model in SD rats,and the rats were randomly divided into 6 groupsthe normal control group,high fat model group,high dose group(1. 5 g·kg-1 ),medium dose group(1. 0 g·kg-1 ),low dose group (0. 5 g·kg-1 )and Xuezhikang group(0. 5 g·kg-1 ). After 35-day treatment,serum TC,TG,HDL-C,LDL-C,SOD,MDA,ALT, AST and liver SOD were detected.Results:
Compared with the model group,hemp seed oil at different dosages could significantly de-crease the contents of serum TC,TG,ALT and the atherogenic index(AI)( P<0. 05 or P<0. 01),and significantly increase the SOD activity in serum and liver(P<0. 01). The contents of serum MDA and AST in the medium and high dose groups were signifi-cantly decreased(P<0. 01),and the content of LDL-C in serum and the content of MDA in liver in the high dose group were signifi-cantly reduced(P<0. 01).Conclusion:
Hemp seed oil shows promising blood lipid reducing ability and liver protective effect in hy-perlipidemic rats,and the mechanism may be related with liver lipid metabolism improvement and antioxidant function enhancement.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Año:
2015
Tipo del documento:
Article