A Case of Idiopathic Light Chain Deposition Disease / 대한신장학회잡지
Korean Journal of Nephrology
; : 146-151, 2005.
Article
en Ko
| WPRIM
| ID: wpr-67223
Biblioteca responsable:
WPRO
ABSTRACT
Light chain deposition disease (LCDD) is a systemic disorder characterized by the deposition of monoclonal immunoglobulin light chains (LCs) in various organs. As LCs are overproduced by an abnormal clone of B cells, LCDD is usually described in the course of plasma cell dyscrasias or other lymphoproliferative disorders. However, it can occur in the absence of any detectable hematological disorder even during prolonged follow-up. We experienced a case of 62-year-woman who presented generalized edema, massive proteinuria and renal insufficiency. The histologic findings showed nodular glomerular mesangial expansion and prominent ribbon like immunohistochemical staining for kappa-light chain in the glomerular capillary wall. There was no evidence of multiple myeloma in bone marrow biopsy specimen. Because she refused the intensive chemothrapy, low dose of prednisolone and cyclophosphamide were prescribed for 6 months. Her renal function was maintained relatively well without renal replacement therapy for 7 months. We report a case of idiopathic LCDD not associated with multiple myeloma or other plasma cell dysclasia.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Paraproteinemias
/
Células Plasmáticas
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Proteinuria
/
Biopsia
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Médula Ósea
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Capilares
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Prednisolona
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Linfocitos B
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Estudios de Seguimiento
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Células Clonales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
Korean Journal of Nephrology
Año:
2005
Tipo del documento:
Article