Antiplasmodial activity of traditional polyherbal remedy from Odisha, India:Their potential for prophylactic use
Asian Pacific Journal of Tropical Biomedicine
; (12): 982-986, 2015.
Article
en Zh
| WPRIM
| ID: wpr-672440
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria. Methods: A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi. Results: The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro (IC50 0.74 mg/mL), a therapeutic index of 9.54. In mice treated with the aqueous extract (2 000 mg/kg/day), peak parasitaemia values were 81% lower in the experimental 2.35% ± 0.14% as compared to controls 12.62% ± 0.52% (P Conclusions: The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.
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WPRIM
Idioma:
Zh
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2015
Tipo del documento:
Article