The model of hypophysis shut off with dexamethasone in rats / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1986.
Article
en Zh
| WPRIM
| ID: wpr-677458
Biblioteca responsable:
WPRO
ABSTRACT
AIM To develop a simple reasonable and provable model of hypophysis shut off in rats with dexamethasone. METHODS Dexamethasone 6 mg?kg -1 was injected subcutaneously into two groups of rats at 300~330 pm on the preceding day. This dose was repeated at 900~930 am next day. The control group was treated with saline in the same way. One hour later, one of the dexamethasone treated groups was ig with Z47 200 mg?kg -1 , the other dexamethasone treated group and the control group was ig with 0 5% CMC. Then all the groups were ip with 0 086 mol?L -1 HAc in order to generate stress reaction. The reduction of the content of Vit C in adrenal gland was taken as the index of secretion of ACTH. RESULTS The content of Vit C in NS CMC HAc was obviously lower than in Dex CMC HAc group. There were statistically significant differences ( P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
1986
Tipo del documento:
Article