Recent Research on CCR5 and Its Antagonists / 中国生物工程杂志
China Biotechnology
; (12)2006.
Article
en Zh
| WPRIM
| ID: wpr-686095
Biblioteca responsable:
WPRO
ABSTRACT
Chemokine receptor 5 (CCR5 ),as a member of the G protein-coupled receptor(GPCR)superfamily,is a membrane protein on cell surface and one of the major of coreceptors for HIV-1infection.CCR5 has became a molecular target for the novel drugs against HIV-1,and antagonists for CCR5 could be grouped as following, chemokine derivatives,small molecule non-peptide compounds,molecular antibodies and peptides. These compounds with high anti-viral activity and affinity are at different stages, and some have been under clinical studies. Therefore, the development research in the different kind of CCR5 antagonists is reviewed.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Biotechnology
Año:
2006
Tipo del documento:
Article