Effect of noninvasive mechanical ventilation in the treatment of obstructive sleep apnea hypopnea syndrome and its effect on serum inflammatory factors / 中国基层医药

ABSTRACT

Objective To investigate the effect of non －invasive ventilator in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS) and the effect on C－reactive protein (CRP),endothelin－1(ET－1) and tumor necrosis factor －alpha (TNF－α).Methods From February 2016 to August 2017,86 patients with moderate and severe OSAHS in the First People's Hospital of Jinzhong were divided into the observation group and the control group according to the different treatment methods ,with 43 cases in each group.The observation group was treated with noninvasive ventilator ,and the control group was treated with conservative treatment .The differences of PSG and inflammatory factors were compared between the two groups before and after treatment ,and the correlation between AHI,ODI,LSpO2,MSpO2and CRP,ET－1,and TNF－αwas analyzed.Results After treatment,AHI,ODI,MSpO2 of the two groups were decreased significantly ,LSpO2increased significantly,and the AHI [(13.7 ±8.6)times/h vs. (43.1 ±13.6)times/h],ODI [(15.4 ±12.9)times/h vs.(42.5 ±12.6)times/h],LSpO2[(79.6 ±16.8)% vs. (62.3 ±19.27)%],MSpO2[(92.2 ±25.6)% vs.(80.3 ±30.4)%] in the observation group were better than those in the control group,the differences were statistically significant (t ＝5.291,4.258,3.998,4.651,all P＜0.05).After treatment,the levels of CRP,ET－1,TNF －αin the observation group were decreased significantly , which in the control group had no statistically significant differences compared with those before treatment .After treat－ ment,the CRP [(3.7 ±0.7)mg/L vs.(6.1 ±1.8)mg/L],ET－1 [(32.3 ±11.9)ng/L vs.(46.5 ±16.6)ng/L], TNF－α[(19.1 ±3.2)ng/L vs.(31.3 ±9.2)ng/L] in the observation group were significantly lower than those in the control group,the difference were statistically significant (t＝8.255,6.594,5.227,all P＜0.05).After Pearson correlation analysis,AHI and ODI were positively correlated with CRP,ET－1 and TNF－α(r＝0.33,0.56,0.44, 0.26,0.55,0.63),while LSpO2and MSpO2were negatively correlated with CRP,ET－1,TNF－α(r＝－0.36,－0.44,－0.54,－0.28,－0.36,－0.59).Among them,the positive correlation coefficient of ODI and TNF －αwas the largest(0.63).The negative correlation coefficient of MSpO2 and TNF－was the largest(－0.59).Conclusion Non－invasive ventilator in the treatment of OSAHS is effective and can obviously reduce the level of inflammatory factors in the body.