Effects of the polymorphsim 5-HTTLPR on the hypersensitive C-reactive protein in patients with de-pression / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the influences of serotonin transporter promoter region (5-HTTLPR)polymorphism on hypersensitive C-reactive protein(hs-CRP)in patients with depression. Method 5-HTTLPR polymorphism was detected by polymerase chain reactive-restriction fragment length polymorphism(PCR-RFLP)in 103 patients with depression and 103 healthy controls.The severity of depres-sion was evaluated by Hamilton Depression Scale(HAMD).The hs-CRP level was tested by immunofluores-cence.The influence of different genotypes on hs-CRP and the interaction of genotype and hs-CRP on the pathogenesis of depression were analyzed. Results The frequency of genotype and allele in 5-HTTLPR was no statistical significant(P=0.81,0.121)among the three groups.There were statistically significant differ-ences in hs-CRP concentration(P=0.007)among the three genotypes of the study group,and the concentra-tion of hs-CRP in SS genotype((8.1±2.7)mg/L)was significantly higher than that in LS((4.9±1.8)mg/L) and LL genotype((5.2±1.3)mg/L)(P=0.002,0.001).The retardation factor in patients were significantly differences in different genotypes(F=4.637,P=0.033).SS genotype(9.3±3.1)was significantly higher than LL(6.1±2.7)and LS genotypes(5.8±2.1)in retardation factor(P=0.008,0.007).Logistic regression analy-sis showed that SS genotype was associated with hs-CRP.The interactive effect was positive related to the morbidity of depression.The correlation of interaction between SS genotype and hs-CRP was greater than LL/LS(OR=1.890,95%CI=1.011-3.396). Conclusion SS genotype of 5-HTTLPR has strengthen effect on hs-CRP.The interaction of genotype and hs-CRP affects the onset of depression.The interaction of SS geno-type and hs-CRP is more likely to effect the onset of depression.