Analysis of short-and long-term outcomes after esophagectomy in elderly cancer pa-tients / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 508-512, 2018.
Article
en Zh
| WPRIM
| ID: wpr-706838
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To analyze the short-and long-term outcomes of elderly patients after esophagectomy by comparing preopera-tive comorbidities, postoperative complications, and survival rates among different age groups.Methods:
We retrospectively reviewed the data of 253 patients who underwent esophagectomy from January to December 2010 in The First Affiliated Hospital of University of Science and Technology of China. Eighty-eight (34.8%) patients were aged<60 years (group A), 145 (57.3%) were aged 60-75 years (group B), and 20 (7.9%) were aged≥75 years (group C). The short-and long-term outcomes of the patients were analyzed.Results:
There were significant differences in three group of patients with hypertension before operation (P<0.05). There were statistically sig-nificant differences among all complications, major complications, pulmonary infection, arrhythmia, and respiratory insufficiency (P<0.05), except for anastomotic leakage and other complications (P>0.05). The mean follow-up was 50.7 months. The median overall sur-vival and 1-, 3-, and 5-year overall survival rates were 68 months and 98.9%, 86.8%, and 69%, respectively, for group A;61 months and 93.1%, 76.1%, and 51%, respectively, for group B;and 32 months and 63.3%, 46%, and 28.8%, respectively, for group C (P<0.001). The median progression-free survival (PFS) and 1-, 3-, and 5-year PFS rates were 60 months and 98.86%, 85.2%, and 45.5%, respectively, for group A;43 months and 87.6%, 53.1%, and 26.9%, respectively, for group B;and 11 months and 30%, 20%, and 10%, respectively, for group C (P<0.001). The differences in survival rates between groups A and B, A and C, and B and C were statistically significant (P<0.001). The multivariate analysis showed that age and TNM stage IV were independent risk factors for overall survival and PFS (P<0.05).Conclusions:
The long-term survival rate decreases significantly in elderly patients with esophageal cancer. In addition, age and advanced pathological stage of tumor are independent risk factors for long-term outcomes.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical Oncology
Año:
2018
Tipo del documento:
Article