Blood Pressure and Heart Rate Variability in Alzheimer's Disease
Dementia and Neurocognitive Disorders
; : 128-134, 2015.
Article
en En
| WPRIM
| ID: wpr-70773
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Altered blood pressure (BP) and heart rate variations (HRVs) have been reported in Alzheimer's disease (AD). However, it is unclear how these two manifestations are associated with AD. Therefore, the objective of this study was to investigate BP and heart rate variability in AD compared to that in normal controls, patients with subjective memory impairment (SMI), and patients with mild cognitive impairment (MCI).METHODS:
Case-control comparisons were made among AD (n=37), MCI (n=24), SMI (n=17), and controls (n=25). All patients underwent clinical and neuropsychological assessments with 24-h ambulatory BP and Holter monitoring.RESULTS:
Patients with AD had higher pulse pressures than those in other groups. In addition, AD patients experienced blunted nocturnal BP dipping associated with declining cognitive status. AD patients also had larger ranges of HRV in parasympathetic domains compared to other groups, especially at night.CONCLUSIONS:
Our results suggest that diurnal sympathetic and parasympathetic cardiac variability were significantly disturbed in mild cholinesterase-naive AD patients. This may be an indirect sign of disturbed integrity to the sleep-wake cycle in mild AD.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Presión Sanguínea
/
Estudios de Casos y Controles
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Electrocardiografía Ambulatoria
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Enfermedad de Alzheimer
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Disfunción Cognitiva
/
Corazón
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Frecuencia Cardíaca
/
Memoria
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Dementia and Neurocognitive Disorders
Año:
2015
Tipo del documento:
Article