Clinical effects of Huoxue Zhuyu Qingdu Decoction combined with routine treatment on patients with sepsis-induced acute kidney injury / 中成药

ABSTRACT

AIM To investigate clinical effects of Huoxue Zhuyu Qingdu Decoction combined with routine treatment on patients with sepsis-induced acute kidney injury.METHODS One hundred and twenty-two patients were randomly and equally divided into control group for a four-week routine treatment,and observation group for a four-week intervention of Huoxue Zhuyu Qingdu Decoction on the basis of routine treatment.RESULTS Significantly decreased post-treatment APACHE Ⅱ,SOFA scores,and TNF-α,IL-6,IL-18,Scr,CysC,NGAL levels in both groups (P ＜ 0.05),and markedly lower values of the indices in the observation group than in the control group were observed (P ＜ 0.05).Meanwhile,the observation group demonstrated its superiority in terms of significantly shorter hospitalization time and lower mortality rate (P ＜ 0.05).CONCLUSION For patients with sepsisinduced acute kidney injury,a combination therapy of Huoxue Zhuyu Qingdu Decoction and routine treatment contributes to a good prognosis due to their synergistic effect in alleviating inflammatory reactions and improving renal injury.