Phenotypic and Genomic Characterization of AmpC-Producing Klebsiella pneumoniae From Korea
Annals of Laboratory Medicine
; : 367-370, 2018.
Article
en En
| WPRIM
| ID: wpr-715636
Biblioteca responsable:
WPRO
ABSTRACT
The prevalence of multidrug-resistant gram-negative bacteria has continuously increased over the past few years; bacterial strains producing AmpC β-lactamases and/or extended-spectrum β-lactamases (ESBLs) are of particular concern. We combined high-resolution whole genome sequencing and phenotypic data to elucidate the mechanisms of resistance to cephamycin and β-lactamase in Korean Klebsiella pneumoniae strains, in which no AmpC-encoding genes were detected by PCR. We identified several genes that alone or in combination can potentially explain the resistance phenotype. We showed that different mechanisms could explain the resistance phenotype, emphasizing the limitations of the PCR and the importance of distinguishing closely-related gene variants.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fenotipo
/
Farmacorresistencia Microbiana
/
Reacción en Cadena de la Polimerasa
/
Prevalencia
/
Genoma
/
Bacterias Gramnegativas
/
Klebsiella
/
Klebsiella pneumoniae
/
Corea (Geográfico)
Tipo de estudio:
Prevalence_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
Annals of Laboratory Medicine
Año:
2018
Tipo del documento:
Article