Clinical Efficacy of Inhaled Nitric Oxide in the Treatment of Persistent Pulmonary Hypertension of the Newborn and Nursing / 沈阳医学院学报

ABSTRACT

Objective:To analysis clinical efficacy of inhaled nitric oxide in the treatment of persistent pulmonary hypertension of the newborn and nursing. Methods: A total of 84 cases of persistent pulmonary hypertension of the newborn received high-frequency oscillation mode of mechanical ventilation at higher ventilation parameters,and inhaled nitric oxide therapy. Before inhalation of nitric oxide and 30 min, 24 h after inhalation of nitric oxide, transcutaneous oxygen saturation (SpO2), blood gas analysis,blood pressure,heart rate,mean arterial blood pressure and oxygenation index (OI) were recorded. Results:There was significant difference in SpO2,PaO2,PaCO2,FiO2,OI at 30 min and 24 h after inhalation of nitric oxide (P<0.05) . There was no significant difference in HR,SPAP,SBP,MAP,pH (P>0.05) .Conclusion:Inhaled nitric oxide combined with a high-frequency oscillation mode of mechanical ventilation in newborns with persistent pulmonary hypertension significantly improve OI,blood gas analysis,oxygen saturation and other indicators,and effective interventions can avoid nitric oxide-related adverse reactions.