A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins
Protein & Cell
; (12): 893-902, 2012.
Article
en En
| WPRIM
| ID: wpr-757847
Biblioteca responsable:
WPRO
ABSTRACT
Nucleocapsid protein (NPs) of negative-sense single-stranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomic RNA and mediate the interaction between genomic RNA and RNA-dependent RNA polymerase. However, recent structural results have revealed other biological functions of -ssRNA viruses that extend our understanding of the versatile roles of virally encoded NPs.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fisiología
/
Virus ARN
/
Química
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Cápside
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Orthobunyavirus
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Proteínas de la Nucleocápside
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Virus Lassa
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Metabolismo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Protein & Cell
Año:
2012
Tipo del documento:
Article