The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson's Disease Patients
Journal of Movement Disorders
; : 172-176, 2019.
Article
en En
| WPRIM
| ID: wpr-765862
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: Impulse control disorders (ICDs) in Parkinson's disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naïve PD patients. METHODS: Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS). RESULTS: Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson's Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naïve PD patients. CONCLUSION: The results of the present study showed that impulsivity negatively influences QOL in early drug-naïve PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Enfermedad de Parkinson
/
Examen Físico
/
Calidad de Vida
/
Dopamina
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Trastornos Disruptivos, del Control de Impulso y de la Conducta
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Conducta Impulsiva
Tipo de estudio:
Qualitative_research
Aspecto:
Patient_preference
Límite:
Female
/
Humans
Idioma:
En
Revista:
Journal of Movement Disorders
Año:
2019
Tipo del documento:
Article