Effects of platelet-derived growth factor on nerve regeneration around implant in rats / 华西口腔医学杂志

ABSTRACT

OBJECTIVE@#To investigate the effect of platelet-derived growth factor (PDGF) on nerve regeneration in peri-implant tissues.@*METHODS@#SD rats with implants in their femurs were injected with PDGF solution. The effects of PDGF on nerve regeneration in peri-implant tissues were analyzed by immunohistochemical staining.@*RESULTS@#PDGF increased the number of nerve fibers in peri-implant tissues at early stage. PDGF had no significant effect on the number of nerve fibers in peri-implant tissues at late stage. Moreover, these nerves had a typical structure of peripheral nerve fibers.@*CONCLUSIONS@#PDGF can promote nerve regeneration in peri-implant tissues at early stage. This study provided a certain experimental basis for the clinical application of PDGF to promote nerve regeneration and further improve the sensory function of the implant.