GAAD: A Gene and Autoimmiune Disease Association Database / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics
; (4): 252-261, 2018.
Article
en En
| WPRIM
| ID: wpr-772976
Biblioteca responsable:
WPRO
ABSTRACT
Autoimmune diseases (ADs) arise from an abnormal immune response of the body against substances and tissues normally present in the body. More than a hundred of ADs have been described in the literature so far. Although their etiology remains largely unclear, various types of ADs tend to share more associated genes with other types of ADs than with non-AD types. Here we present GAAD, a gene and AD association database. In GAAD, we collected 44,762 associations between 49 ADs and 4249 genes from public databases and MEDLINE documents. We manually verified the associations to ensure the quality and credibility. We reconstructed and recapitulated the relationships among ADs using their shared genes, which further validated the quality of our data. We also provided a list of significantly co-occurring gene pairs among ADs; with embedded tools, users can query gene co-occurrences and construct customized co-occurrence network with genes of interest. To make GAAD more straightforward to experimental biologists and medical scientists, we extracted additional information describing the associations through text mining, including the putative diagnostic value of the associations, type and position of gene polymorphisms, expression changes of implicated genes, as well as the phenotypical consequences, and grouped the associations accordingly. GAAD is freely available at http//gaad.medgenius.info.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Enfermedades Autoinmunes
/
Bases de Datos Factuales
/
Redes Reguladoras de Genes
/
Estudios de Asociación Genética
/
Minería de Datos
/
Genética
Límite:
Humans
Idioma:
En
Revista:
Genomics, Proteomics & Bioinformatics
Año:
2018
Tipo del documento:
Article