Relationship between Quantitative Monitoring of WT1 Gene and Prognosis in Patients with Acute Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1632-1636, 2018.
Article
en Zh
| WPRIM
| ID: wpr-773044
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the exprassion of WT1 gene in patients with adult acute myeloid leukemia (AML) and its clinical significance.@*METHODS@#Sixty-three newly diagnosed patients with acute myeloid leukemia were selected. Quantitative RT-PCR was used to detect the expression of WT1 gene in the 63 AML patients and 20 non-AML controls.@*RESULTS@#WT1 gene was highly expressed in AML patents and its expression in the low-risk group was significantly lower than that in middle-risk group and high-risk group (P<0.05), and no significant difference of WT1 gene expression between middle-risk and high-risk group was observed. In the patients of middle-risk and high-risk patients, the expression of WT1 gene in the remission group was significantly lower than that in the patients of non-remission after treatment (P<0.05). The non-remission patients after first treatment in middle-risk and high-risk group were treated with second induction therapy. After second induction therapy, the WT1 expression in remission patients was significantly decreased (P<0.05) in comparison with that in patients still in non-remission. There was a negative correlation between WT1 expression and the 2-year overall survival rate in the newly diagnosed middle and high-risk AML patients.@*CONCLUSION@#The detection of WT1 gene expression can help to divide AML patients into low-/middle-/high-risk groups and to evaluate therapeutic response and clinical prognosis in middle and high-risk AML patients.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
/
Leucemia Mieloide Aguda
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Expresión Génica
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Enfermedad Aguda
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Neoplasia Residual
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Proteínas WT1
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2018
Tipo del documento:
Article