Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 22-26, 2019.
Article
en En
| WPRIM
| ID: wpr-776909
Biblioteca responsable:
WPRO
ABSTRACT
Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC of 2.6 and 3.8 μmol·L, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
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Plantas Comestibles
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Plantas Medicinales
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Triterpenos
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Extractos Vegetales
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Estructura Molecular
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Supervivencia Celular
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Química
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Factor de Necrosis Tumoral alfa
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Cirsium
Límite:
Animals
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Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2019
Tipo del documento:
Article