Performance Evaluation of the CS-5100 Coagulation Analyzer for Special Coagulation Parameters
Laboratory Medicine Online
; : 25-32, 2020.
Article
en En
| WPRIM
| ID: wpr-782251
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: The CS-5100 high-throughput automated coagulometer (Sysmex, Japan) can perform general and special coagulation assays. We evaluated the performance of the CS-5100 coagulometer to measure fibrinogen degradation product (FDP), plasma level of unfractionated heparin (UFH), low molecular weight heparin (LMWH), and direct oral anticoagulants (DOACs).METHODS:
Precision, linearity, and carryover rate of the CS-5100 while measuring FDP, UFH, and LMWH were validated. Precision and linearity were validated for measurements of DOACs. Results of FDP measurement using CS-5100 were compared to those using the currently used STA-R coagulometer (Diagnostica Stago, France). The reference range of FDP was established. All evaluation procedures were in accordance with Clinical and Laboratory Standards Institute guidelines.RESULTS:
CS-5100 displayed good precision, linearity, and carryover rate for measuring FDP, UFH, LMWH, and DOACs. The FDP level measured with the CS-5100 and STA-R coagulometers correlated well. The reference range of FDP with CS-5100 was 0.0 to 3.48 µg/mL.CONCLUSIONS:
The CS-5100 coagulometer has acceptable analytical performance in measuring special coagulation parameters. It is suitable for the reliable measurement of plasma FDP and anticoagulant levels in clinical laboratories.Palabras clave
Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Plasma
/
Valores de Referencia
/
Fibrinógeno
/
Heparina
/
Heparina de Bajo-Peso-Molecular
/
Anticoagulantes
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Laboratory Medicine Online
Año:
2020
Tipo del documento:
Article