An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 108-116, 2011.
Article
en En
| WPRIM
| ID: wpr-78353
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of JAK3 contributes to the development of lung cancer. This study investigated whether polymorphisms at the promoter region of the JAK3 gene are associated with the risk of lung cancer in the Korean population. MATERIALS AND METHODS: A total of 819 subjects, including 409 lung cancer patients and 410 healthy controls were recruited. The SNaPshot assay and polymerase chain reaction-restriction fragment length polymorphism analysis were used, and logistic regression analyses were performed to characterize the association between polymorphisms of JAK3 and lung cancer risk. RESULTS: Three polymorphisms (-672 G>A, +64 A>G and +227 G>A) of JAK3 were analyzed for large-scale genotyping (n=819). Statistical analyses revealed that polymorphisms and haplotypes in the JAK3 gene were not significantly associated with lung cancer. CONCLUSION: JAK3 gene was not significantly associated with the risk of lung cancer in the Korean population.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Haplotipos
/
Proteínas Tirosina Quinasas
/
Modelos Logísticos
/
Regiones Promotoras Genéticas
/
Quinasas Janus
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Janus Quinasa 3
/
Corea (Geográfico)
/
Pulmón
/
Neoplasias Pulmonares
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Cancer Research and Treatment
Año:
2011
Tipo del documento:
Article