Your browser doesn't support javascript.
loading
A new alkaloid from Rehmanniae Radix Preparata / 药学学报
Acta Pharmaceutica Sinica ; (12): 289-293, 2020.
Article en Zh | WPRIM | ID: wpr-789031
Biblioteca responsable: WPRO
ABSTRACT
The chemical constituents of Rehmanniae Radix Preparatawere prepared according to the traditional method of "jiu zheng jiu shai" and investigated using multiple chromatographic methods. Six alkaloids were isolated and their structures were elucidated from spectral data and physicochemical properties, as follows: rehmanniae alkaloid A (4-{[(5-O-á-D-galactopyranosyloxy)methyl]-1H-pyrrole-2-carbaldehyde-1-yl}butyric acidmethyl ester) (1), baimantuoluoamide B (2), capparisine C (3), harman-3-carboxylic acid (4), (2S)-1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carboxylate (5), and 1-[2-(furan-2-yl)-2-oxoethyl]pyrrolidin-2-one (6). Among them, compound 1 is a new alkaloid. Compounds 2-6 were newly isolated from Rehmannia glutinosa Libosch.The effect of compounds 1-6 on NRK-52e cell injury induced by LPS was investigated. The results show that compounds 1-3 exhibit protective effects against LPS-induced damage to NRK-52e cells.
Palabras clave
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Acta Pharmaceutica Sinica Año: 2020 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Acta Pharmaceutica Sinica Año: 2020 Tipo del documento: Article