Expression and clinical significance of HIF-1α and OPN in esophageal cancer tissues / 国际肿瘤学杂志

ABSTRACT

Objective To discuss the expression and clinical significance of hypoxia-inducible factor-1α (HIF-1α) and osteopontin (OPN) in esophageal cancer tissues.Methods A total of 100 patients with esophageal cancer in Enshi Tujia and Miao Autonomous Prefecture Central Hospital of Hubei Province from January 2015 to January 2017 were selected.The expressions of HIF-1α and OPN in esophageal cancer and adjacent tissues were detected by immunohistochemistry.The relationships between HIF-1α and OPN expressions and clinical pathological characteristics of esophageal cancer patients,as well as the correlation between them were analyzed.Results The positive rates of HIF-1α and OPN expression in esophageal cancer tissues were 70.00％ (70/100) and 64.00％ (64/100),which were significantly higher than the 14.00％ (14/100) and 8.00％ (8/100) in adjacent tissues,and the differences were statistically significant (x2=64.368,P ＜ 0.001;x2 =68.056,P ＜0.001).The expression of HIF-1α was correlated with TNM stage,depth of invasion and lymph node metastasis (x2 =30.159,P ＜ 0.001;x2 =17.493,P ＜ 0.001;x2 =16.357,P ＜ 0.001),but it was not correlated with sex,age,tumor diameter and differentiation (all P ＞ 0.05).The expression of OPN was correlated with TNM stage,depth of invasion and lymph node metastasis (x2 =12.558,P =0.002;/x2 =15.395,P ＜ 0.001;x2 =17.056,P ＜ 0.001),but it was not correlated with sex,age,tumor diameter and differentiation (all P ＞ 0.05).There was the positive correlation between HIF-1α and OPN expression in esophageal cancer tissues (x2 =61.144,P ＜ 0.001,C =0.616).The 2-year survival rates of HIF-1α and OPN positive patients in esophageal cancer tissues were 51.43％ and 50.00％ respectively,which were significantly lower than those of HIF-1α and OPN negative patients (80.00％ and 77.78％),and the differences were statistically significant (x2 =7.143,P =0.008;x2 =7.407,P =0.006).Conclusion HIF-1 α and OPN are highly expressed in esophageal cancer tissues,and their high expression may be related to poor survival prognosis of esophageal cancer.