Predictors of Avascular Necrosis after Kidney Transplantation / 대한이식학회지
The Journal of the Korean Society for Transplantation
; : 200-206, 2017.
Article
en En
| WPRIM
| ID: wpr-79169
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Risk factors for bone avascular necrosis (AVN), a common late complication after kidney transplantation (KT), are not well known. METHODS: Patients that underwent living-donor KT at Asan Medical Center between January 2009 and July 2016 were included in this retrospective study to determine the incidence and risk factors for AVN after KT. RESULTS: Among 1,570 patients that underwent living-donor KT, 33 (2.1%) developed AVN during a mean follow-up of 49.8±25.0months. Additionally, AVN was diagnosed at a mean of 13.9±6.6 months after KT. The mean cumulative corticosteroid dose during the last follow-up in patients without AVN (9,108±3,400 mg) was higher than that that in patients with AVN (4,483±1,114 mg) until AVN development (P < 0.01). More patients among those with AVN (n=4, 12.1%) underwent steroid pulse treatment because of biopsy-proven rejections during the first 6 months after KT than patients without AVN (n=68, 4.4%; P=0.04). Female (hazard ratio [HR], 2.29; P=0.04) and steroid pulse treatment during the first 6 months (HR, 2.31; P=0.02) were significant AVN risk factors as revealed by the Cox proportional multivariate analysis. However, no significant differences in rejection-free graft survival rates were observed between the two groups (P=0.67). CONCLUSIONS: Steroid pulse treatment within 6 months of KT and being female were independent risk factors for AVN development.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteonecrosis
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Incidencia
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Análisis Multivariante
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Estudios Retrospectivos
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Factores de Riesgo
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Estudios de Seguimiento
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Terapia de Inmunosupresión
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Trasplante de Riñón
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Supervivencia de Injerto
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Riñón
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
Idioma:
En
Revista:
The Journal of the Korean Society for Transplantation
Año:
2017
Tipo del documento:
Article