Emphasis on biomaterial research in bone defect repair of osteoporotic fracture / 中华创伤杂志

ABSTRACT

Osteoporosis results in decreased bone mass, impaired bone strength and bone microstructure, and thus can easily cause bone fracture. Osteoporosis is one of the common diseases troubling the aging people. Due to the decreased activity of osteoblasts as well as impaired osteogenic differentiation of mesenchymal stem cells, the repair of bone defects accompanied with osteoporosis is very limited. It is a promising way to enhance the healing effect of such bone defect through implanting biomaterials with improved physical and chemical properties as well as elevated bioactivities, since it can mediate the activities of osteogenesis related cells in situ. The author summarizes the popular methods for the modification of biomaterials used for repairing bone defect caused by osteoporotic fractures and provides a prospect in this field, with the aim to provide a reference for the treatment of osteoporotic fractures.